Lyrica (Pregabalin)

Overview

What is Lyrica? 

Lyrica, known by its generic name Pregabalin, is a medication that is prescribed as an analgesic and anticonvulsant.  

Pregabalin is a gamma-aminobutyric acid (GABA) analogue, synthesized to bind to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. 

Global Name

Generic name:  Pregabalin
Brand names: Prebictal, Alzain, Maxgalin, Rewisca  

Usage

What is Lyrica used for? 

Lyrica is used to treat nerve pain associated with various conditions like diabetic neuropathy, spinal cord injuries, fibromyalgia, and as an adjunct therapy for partial onset seizures in adults. 

How do you use Lyrica? 

Availability:

Lyrica is available in capsule, oral solution, and extended-release tablet forms. 

Dosage information: 

• Start with a lower dose and gradually increase as directed by a healthcare provider. 
• Dosage varies based on the condition being treated and the patient's response to therapy.

Suitability: 

• Children: Not typically prescribed for children. 
• Adults: Yes, for appropriate indications and dosages. 
• Elderlies: Dose adjustment may be necessary based on renal function.  

Is there anyone who can’t take Lyrica? 

• Children: Not recommended except for managing seizures as prescribed. 
• Adults: Adults with hypersensitivity or severe renal impairment must be cautious. 
• Elderlies: Dose adjustments may be needed for reduced kidney function. 
• Pregnancy and Lactation: continue to avoid use of pregabalin during pregnancy unless clearly necessary and only if the benefit to the patient clearly outweighs the potential risk to the fetus – ensure the patient has a full understanding of the benefits, risks, and alternatives, and is part of the decision-making process  
• Patients with known hypersensitivity to Lyrica or a history of angioedema 

Any warnings and precautions : 

Lyrica may cause dizziness, sleepiness, and can lead to dependency or withdrawal symptoms. It should not be abruptly discontinued. 

Drug and Food/Beverage Interactions: 

Lyrica can interact with other medications that cause sedation and can have additive effect, such as opioids, benzodiazepines, and anti-allergy drugs.  Concomitant intake of alcohol can exacerbate the sedating effect of Lyrica, hence it is not advised. 

Side Effects

Common side effects include drowsiness, dizziness, blurred vision, weight gain, and difficulty concentrating.  

Pharmacist Tips

• Starting the Medication: When beginning treatment with Lyrica, it's important to start with the lowest possible dose and gradually increase it as advised by your healthcare provider. This helps minimize side effects. 
• Consistent Schedule: Try to take your doses at the same times each day to maintain an even level of medication in your body. Consistent dosing can also help avoid missed doses. 
• Managing Side Effects: If you experience dizziness or sleepiness, avoid activities that require mental alertness until these side effects subside. If these effects are severe or persistent, consult your healthcare provider. 
• Withdrawal Symptoms: Do not stop taking Lyrica abruptly without consulting your doctor, as this may cause withdrawal symptoms such as insomnia, nausea, headache, and diarrhea. Your healthcare provider will guide you on how to taper off the medicine safely. 
• Overdose Awareness: Be aware of the symptoms of an overdose, which can include blurred vision, difficulty breathing, and extreme sleepiness. Seek immediate medical attention if you suspect an overdose. 

• Pregnancy and Nursing: There are as yet no current studies establishing safety in pregnancy. The drug can be excreted in milk, hence is not recommended for use by nursing mothers.
• Storage Information: Keep Lyrica in a secure place out of reach of children and pets and store it at room temperature away from excess heat and moisture (not in the bathroom). 
• Handling Instructions: If you are using the oral solution, ensure that it is measured with an accurate dosing syringe or cup. Do not use household utensils to measure the liquid form. 
• Disposal of Unused Medication: If you have leftover or expired Lyrica, do not dispose of it in household trash or wastewater. Consult your pharmacist or local waste disposal company for proper disposal instructions to help protect the environment and others from potential harm. 
• Traveling with Medication: When traveling, keep Lyrica in its original labeled container and bring a copy of your prescription. Be aware of regulations if you are traveling internationally, as some countries have specific rules regarding controlled substances. 

Availability

Where is Lyrica available in Hong Kong?

Lyrica is a prescription medication that can be prescribed by healthcare providers then bought in authorized pharmacies. 

FAQs

Is Lyrica considered a narcotic?

No, Lyrica is not a narcotic, but it is classified as a Schedule V controlled substance due to potential for abuse. 

Can I drink alcohol while taking Lyrica?

It is best to avoid alcohol as it can increase the chance of experiencing side effects like dizziness. 

Is Lyrica available for purchase over the counter?

No, Lyrica is a prescription medication and requires a healthcare provider's approval. 

What not to take with Lyrica?

• Central nervous system (CNS) depressants, such as opioids, benzodiazepines, alcohol, or sleep medications 
• Antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) 

• Diabetes medications, as Lyrica may affect blood sugar levels 
• Antihypertensive medications, as Lyrica may cause a slight increase in blood pressure 
• Sedatives, sleep aids, or substances that can cause sedation