LEQVIO (Inclisiran)

Overview

LEQVIO, with the generic name inclisiran, is a novel cholesterol-lowering medication. Unlike traditional statins, LEQVIO works by silencing a specific gene in the liver, improving the regulation of the Low-density lipoproteins (LDLs), or the bad cholesterol. 

Contents and Ingredients 

• Active Ingredient: Inclisiran 

Chemical Structure and Manufacture 

LEQVIO is a small interfering RNA (siRNA) therapy, synthesised through advanced biotechnological processes targeting the PCSK9 gene, which plays a crucial role in regulating cholesterol. 

Global Name

• Generic Name: Inclisiran
• Brand Name: LEQVIO 

Usage

What is LEQVIO used for?

LEQVIO is used to treat: 

• Hypercholesterolemia (elevated cholesterol levels) 
• Heterozygous familial hypercholesterolemia (genetically related) 
• Mixed Dyslipidemia 
  It serves as an adjunct to diet and maximally tolerated statin therapy. 

How do you use LEQVIO? 

Dosage Information 

• Administered as a subcutaneous injection. 
• Initial doses at Day 1 and Day 90, followed by a maintenance dose every 6 months. 

Suitability 

• Suitable for adults with clinical atherosclerotic cardiovascular disease or heterozygous familial hypercholesterolemia. 
• Not recommended for children or adolescents. 

Contraindications 

• Individuals with active liver disease or severe renal impairment. 
• Pregnancy and breastfeeding women. 

Allergy Information 

• Patients with a known allergy to Inclisiran or excipients in LEQVIO. 

Warnings and Precautions 

• Monitor liver enzymes and renal function. 
• No food restrictions related to the timing of the injection. 

Interactions and Contraindications 

• Unknown interactions with other lipid-lowering therapies. 
• Avoid in patients with a history of a life-threatening reaction to similar drugs. 

Side Effects

Common side effects may include injection site reactions, joint pain, urinary tract infections, diarrhoea, and chest pain. 

Note: Always report concerning side effects to your healthcare provider. 

Pharmacist Tips

Storage Information 

• Store at room temperature. 
• Protect from light. 

Handling Instructions 

• Allow LEQVIO to reach room temperature before administration. 
• Do not shake the vial. 

Availability

Where is LEQVIO available in Hong Kong?

Availability in Hong Kong

LEQVIO is a prescription medication that can be prescribed by healthcare providers.

FAQs

How often is LEQVIO administered? 

Can LEQVIO replace statins?

LEQVIO is used in conjunction with statins, not as a replacement.

Is LEQVIO a pill?

No, LEQVIO is an injectable medication.

Does LEQVIO interact with other medications?

There are no known significant interactions, but always consult your healthcare provider.

What happens if I miss a dose?

Depends on the next planned dose schedule. If a planned dose is missed by more than 3 months, consult your healthcare provider as you may need to restart with a new dosing schedule.