Febuxostat

Overview

What is Febuxostat? 

Febuxostat is a xanthine oxidase inhibitor used to lower uric acid levels in the blood. 

Febuxostat is synthesized through a complex chemical process to inhibit the enzyme xanthine oxidase, responsible for uric acid production. 

Global Name

Generic name: Febuxostat 
Brand names: Uloric, Adenuric, Feburic 

Usage

What is Febuxostat used for? 

Febuxostat is primarily used for the chronic (long-term/maintenance) management of hyperuricemia in patients with gout. 

How do you use Febuxostat? 

Availability:

Febuxostat is available in tablet form. 

Dosage information: 

• Adults: The typical starting dose is 40 mg once daily, which may be increased to 80 mg if uric acid levels remain high. 
• Children: Not typically recommended for children. 

Suitability: 

• Children: Febuxostat is generally not recommended for use in children. 
• Adults: Suitable for adult patients. 
• Elderlies: Can be used in elderly patients; however, dose adjustment may be necessary based on renal function.

• Allergies: Patients with a known hypersensitivity to Febuxostat or its components should not use this medication. 

Is there anyone who can’t take Febuxostat? 

• Children: The safety and effectiveness of Febuxostat in pediatric patients have not been established. 
• Adults: Adults with severe renal or hepatic impairment should avoid Febuxostat. 
• Elderlies: No absolute contraindication, but caution is advised. 
• Pregnancy and Lactation: Febuxostat should only be used if the potential benefit justifies the potential risk to the fetus. Please consult with a medical professional. 

Any warnings and precautions : 

Febuxostat may increase the risk of cardiovascular events. Patients with a history of heart disease should use it with caution. 

Interactions: 
Febuxostat may interact with azathioprine, mercaptopurine, and theophylline. It should not be used by patients on these medications without a doctor’s supervision. 

Side Effects

Common side effects include liver enzyme abnormalities, nausea, joint pain, and rash. Serious side effects can include heart-related events and severe allergic reactions. 

Pharmacist Tips

• Regular Testing: While on Febuxostat, regular blood tests to monitor your uric acid levels and liver function are crucial. 
• Fluid Intake: Increase your fluid intake to help reduce uric acid concentrations and prevent kidney stones. 
• Dietary Considerations: Maintain a balanced diet low in purines, which can contribute to uric acid buildup. 
• Gout Flare Prophylaxis: Your doctor may prescribe an additional medication to prevent gout flares when you start taking Febuxostat. 
• Adherence to Therapy: Do not stop taking Febuxostat without consulting your healthcare provider, as abruptly stopping can lead to gout flares. 
• Storage Information: Store Febuxostat at room temperature, away from moisture and heat. 
• Handling Instructions: Handle with clean, dry hands and consume immediately after removing from the packaging. 

Availability

Where is Febuxostat available in Hong Kong?

Febuxostat  is a prescription medication that can be prescribed by healthcare providers and bought in pharmacies. 

FAQs

Can I take Febuxostat during a gout attack?

Febuxostat is not meant for acute gout attacks but for long-term management of uric acid levels. 

How long does it take for Febuxostat to work? 

Is Febuxostat available for purchase over the counter?

No, Febuxostat requires a doctor's prescription. 

When to stop Febuxostat?

The decision to stop taking febuxostat should be made in consultation with a healthcare professional, such as a doctor or rheumatologist, who can assess your specific medical condition and treatment needs.